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Furthermore, in a mouse model, P-selectin in neutrophils activated the synergistic effects of PSGL-1 and C-X-C motif chemokine receptor 2 (CXCR2), thereby promoting neutrophil adhesion in blood flow-restricted veins, stimulating the release of NETs, and ultimately leading to deep vein thrombosis (123, 124)

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Moreover, cfDNA combined with CRP can serve as valuable biomarkers for assessing the severity of sepsis and is particularly useful in differentiating complex bloodstream infections from milder forms